Jon WilcoxMonday 22 May 2006, 2:45PM
The
wonderful thing about that big library in cyberspace, which is the
internet, is the occasional pot of gold which turns up out of the
blue. The pot of gold might be a public domain postdoctoral thesis
on mediaeval history stored away in some obscure university
e-archives, or it might be a curiously unique website devoted to
the role of C-reactive protein and inflammation in cardiovascular
disease.
For those seemingly eccentric clinicians with a decade or more of
fascination with the role of infection, inflammatory diseases,
inflammatory triggers and inflammatory markers and the association
of small and large vessel arterial disease fluctuations, CRPhealth will provide a bucket-load of
information, abstracts, publications and other resources to firmly
remind us of just how much we still do not fully understand in the
otherwise over-published and increasingly globalised world that is
modern medicine. (One could say the evidence based
medicine-obsessed modern world of medicine but it is appropriately
and gratifyingly noted BPAC really likes CRPs and doesn't like
ESRs.)
While the role of CRPhealth in arterial diseases has not yet
substantially embedded itself into so-and-so's "evidence that
matters" or the "Middle Earth Guidelines Group cardiovascular guide
for optimal primary heart care", there is an increasing, albeit
somewhat ambulatory acceptance within the cardiology community that
inflammation, endothelial and intimal dysfunction might (just
conceivably) go hand in hand.
CRPhealth is a sponsored site thanks to Novartis, Sandoz and a
technology company called Behring (which of course just happens to
make machines that measure CRP).
But the editorial board of six includes reputable cardiovascular
professors and lipidologists from Harvard, Germany and Texas.
Despite the sponsorship, it is, however, disappointing the site
does not appear to provide any full text article references and
most references and links at this time are to abstracts only. It is
hoped sponsorships in future will allow suitable access to full
text articles.
Indeed, comprehensive and authoritative review articles such as:
"The metabolic syndrome: inflammation, diabetes mellitus, and
cardiovascular disease," from a referenced January 2006
American Journal of Cardiology issue, only offers the full
article through the e-publishing affiliate Science Direct for the
completely absurd and unattractive price of US$30.
So, while thumbnail abstracts for certain references may be useful
for succinct niche research publications, abstracts of review
articles tend to be close to useless.
CRPhealth is not an elaborate or complicated website. It has two
main components - a professional section and a consumer section.
Both sections give a brief background about the significance of CRP
and inflammation in cardiovascular disease under headings, what is
CRP, guidelines, clinical trial summaries and a discussion
forum.
There are also online audio presentations, powerpoint
presentations, a video and slide library and other resources
available. CRPhealth is well worth a visit and if the site remains
well maintained may serve as a useful trigger for important new
publications dealing with the future role of inflammation in
cardiovascular disease.
We can but hope their generous sponsorship will eventually extend
to full text articles.