For older people and frail people, the long-term benefit of medicines reduces and the potential for harm from adverse effects increases. When the benefit–risk balance changes in this way, medicine review and optimisation are important to simplify the therapeutic regimen, reduce inappropriate medicines and minimise risks. In this article, pharmacist prescriber Linda Bryant uses two case studies to illustrate important considerations during medicine reviews
Anticoagulation for atrial fibrillation detected by device

Consultant cardiologist Chris Ellis looks at the management of short runs of atrial fibrillation detected by pacemaker
Kia ora and welcome to New Zealand Doctor Rata Aotearoa
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2. Glotzer TV, Daoud EG, Wyse DG, et al. The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study. Circ Arrhythm Electrophysiol 2009;2(5):474–80.
3. Van Gelder IC, Healey JS, Crijns HJGM, et al. Duration of devicedetected subclinical atrial fibrillation and occurrence of stroke in ASSERT. Eur Heart J 2017;38(17):1339–44.