Goodfellow Gems #62

Goodfellow Gems #62

Bruce Arroll

Bruce Arroll

goodfellow gem

Most antidepressant benefit seen in primary care is due to placebo. Talk first prescribe later.

An update to a Cochrane review on antidepressants in primary care found that the most of the benefit was due to the placebo.1 For tricyclics, 63% o
References

1.    Arroll et al. Antidepressants for treatment of depression in primary care. A systematic review and meta-analysis. 2016 http://www.publish.csiro.au/HC/pdf/HC16008
2.    Fournier et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 2010. https://www.ncbi.nlm.nih.gov/pubmed/20051569
3.    Depression in adults: recognition and management. NICE Guidance (CG90). https://www.nice.org.uk/guidance/cg90