Goodfellow Gems #62

Goodfellow Gems #62

Bruce Arroll

Bruce Arroll

goodfellow gem

Most antidepressant benefit seen in primary care is due to placebo. Talk first prescribe later.

An update to a Cochrane review on antidepressants in primary care found that the most of the benefit was due to the placebo.1
References

1.    Arroll et al. Antidepressants for treatment of depression in primary care. A systematic review and meta-analysis. 2016 http://www.publish.csiro.au/HC/pdf/HC16008
2.    Fournier et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 2010. https://www.ncbi.nlm.nih.gov/pubmed/20051569
3.    Depression in adults: recognition and management. NICE Guidance (CG90). https://www.nice.org.uk/guidance/cg90