For older people and frail people, the long-term benefit of medicines reduces and the potential for harm from adverse effects increases. When the benefit–risk balance changes in this way, medicine review and optimisation are important to simplify the therapeutic regimen, reduce inappropriate medicines and minimise risks. In this article, pharmacist prescriber Linda Bryant uses two case studies to illustrate important considerations during medicine reviews
Exposing fraud is no feel-good exercise but worth it for the sake of science
Exposing fraud is no feel-good exercise but worth it for the sake of science

We are on our summer break and the editorial office is closed until 14 January. We hope you enjoy this article which is part of Summer Hiatus, an eclectic mix from our archives throughout the year, The Conversation and other publications we share content with. Please note the comment function has been turned off while we are away. Happy reading
Kia ora and welcome to New Zealand Doctor Rata Aotearoa
Not a subscriber? Unlock this article by subscribing here.
1.Bolland MJ, Avenell A, Gamble GD et al. Systematic review and statistical analysis of the integrity of 33 randomized controlled trials. Neurology 2016;87:2391–2402.
2.Cockayne S, Adamson J, Lanham-New S, et al. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomised controlled trials. Arch Intern Med 2006;166(12):1256-1261.
3. Grey A, Avenell A, Bolland M. Revised Meta-analysis of vitamin K and fractures. JAMA Internal Medicine (formerly Arch Intern Med) 2018;178,8:1135.