For older people and frail people, the long-term benefit of medicines reduces and the potential for harm from adverse effects increases. When the benefit–risk balance changes in this way, medicine review and optimisation are important to simplify the therapeutic regimen, reduce inappropriate medicines and minimise risks. In this article, pharmacist prescriber Linda Bryant uses two case studies to illustrate important considerations during medicine reviews
Depression in older people must be taken seriously
Depression in older people must be taken seriously

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This article was first published online on 27 March.
Specialist GP Ngaire Kerse examines depression in older people, including how to manage treatment-resistant depression
Kia ora and welcome to New Zealand Doctor Rata Aotearoa
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1. Steffens DC. Treatment-resistant depression in older adults. N Engl J Med 2024;390(7):630–39.
2. Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 2006;163(11):1905–17.