For older people and frail people, the long-term benefit of medicines reduces and the potential for harm from adverse effects increases. When the benefit–risk balance changes in this way, medicine review and optimisation are important to simplify the therapeutic regimen, reduce inappropriate medicines and minimise risks. In this article, pharmacist prescriber Linda Bryant uses two case studies to illustrate important considerations during medicine reviews
Speeding past science and advice
Speeding past science and advice

From speed limits to cancer screening, Simeon Brown keeps ignoring advice in favour of his own reality, says Jim Vause
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1Government promises to further drop bowel cancer screening age. RNZ, 7 March 2025. Available online at https://tinyurl.com/mwc5w5p8
2Simeon Brown appointed prominent oil, gas lobbyist to energy savings board against official advice RNZ, 6 March 2025. Available online at https://tinyurl.com/mvr5ubmp
3Proactive OIA releases. NZTA Waka Kotahi 2024. Available online at https://tinyurl.com/bdh92jae
4Evidence shows increased speed limits will cost NZ in money as well as lives. 1News, 4 March 25 Available online at https://tinyurl.com/muv8ktme
5Proactive OIA releases. NZTA Waka Kotahi 2024. Available online at https://tinyurl.com/bdh92jae
6Proactive OIA releases. NZTA Waka Kotahi 2024. Available online at https://tinyurl.com/bdh92jae