Entering the ‘battle’ between precision and evidence-based medicine

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PRACTICE

Entering the ‘battle’ between precision and evidence-based medicine

18 July 2018

Jo Scott-Jones

Wednesday 18 July 2018, 02:00 AM

Are GPs ready to wrestle with evidence-based and precision medicine?

Comprehensive information about specific gene variants and their impact on diagnosis and treatment is now available in an easily searchable database – it’s time to get to grips with genomics

Of patients who experience allopurinol-induced severe cutaneous adverse reactions (SCAR), 25–30 per cent die Dr William Ferguson’s call to arms i

Genomic Medicine

References

1. Taylor C. ‘A battle is looming’ - GP urges docs to join the genomics revolution. www.nzdoctor.co.nz/article/news/battle-looming-gp-urges-docs-join-genomics-revolution

2. Medsafe. Pharmacogenomics – helps reduce rash decisions. Prescriber Update 2018:39(2);25–27. https://bit.ly/2M4k9kR

3. Whirl-Carrillo M, McDonagh EM, Hebert JM et al. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther 2012;92(4):414–17.

4. Rademaker M. Drug hypersensitivity syndrome. DermNet NZ 2004, updated 2016. www.dermnetnz.org

5. Keller SF, Lu N, Blumenthal KG et al. Racial/ethnic variation and risk factors for allopurinol-associated severe cutaneous adverse reactions: a cohort study. Ann Rheum Dis 2018; doi: 10.1136/annrheumdis-2017-212905 (Epub ahead of print)

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How to Treat

+How to treat

Polypharmacy

For older people and frail people, the long-term benefit of medicines reduces and the potential for harm from adverse effects increases. When the benefit–risk balance changes in this way, medicine review and optimisation are important to simplify the therapeutic regimen, reduce inappropriate medicines and minimise risks. In this article, pharmacist prescriber Linda Bryant uses two case studies to illustrate important considerations during medicine reviews

Wednesday 28 May 2025, 12:50 AM