For older people and frail people, the long-term benefit of medicines reduces and the potential for harm from adverse effects increases. When the benefit–risk balance changes in this way, medicine review and optimisation are important to simplify the therapeutic regimen, reduce inappropriate medicines and minimise risks. In this article, pharmacist prescriber Linda Bryant uses two case studies to illustrate important considerations during medicine reviews
COVID-19 variant of interest JN.1
COVID-19 variant of interest JN.1

Due to its rapidly increasing spread, WHO is classifying the variant JN.1 as a separate variant of interest (VOI) from the parent lineage BA.2.86. It was previously classified as VOI as part of BA.2.86 sublineages.
Based on the available evidence, the additional global public health risk posed by JN.1 is currently evaluated as low. Despite this, with the onset of winter in the Northern Hemisphere, JN.1 could increase the burden of respiratory infections in many countries.
WHO is continuously monitoring the evidence and will update the JN.1 risk evaluation as needed.
Current vaccines continue to protect against severe disease and death from JN.1 and other circulating variants of SARS-CoV-2, the virus that causes COVID-19.
COVID-19 is not the only respiratory disease circulating. Influenza, RSV and common childhood pneumonia are on the rise.
WHO advises people to take measures to prevent infections and severe disease using all available tools. These include:
- Wear a mask when in crowded, enclosed, or poorly ventilated areas, and keep a safe distance from others, as feasible
- Improve ventilation
- Practise respiratory etiquette - covering coughs and sneezes
- Clean your hands regularly
- Stay up to date with vaccinations against COVID-19 and influenza, especially if you are at high risk for severe disease
- Stay home if you are sick
- Get tested if you have symptoms, or if you might have been exposed to someone with COVID-19 or influenza
For health workers and health facilities, WHO advises:
- Universal masking in health facilities, as well as appropriate masking, respirators and other PPE for health workers caring for suspected and confirmed COVID-19 patients.
- Improve ventilation in health facilities